Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
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چکیده
منابع مشابه
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.
The tyrosine kinase activity of the insulin receptor was examined with partially-purified insulin receptors from adipocytes obtained from 13 lean nondiabetics, 14 obese nondiabetics, and 13 obese subjects with non-insulin-dependent diabetes (NIDDM). Incubation of receptors at 4 degrees C with [gamma-32P]ATP and insulin resulted in a maximal 10-12-fold increase in autophosphorylation of the 92-k...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1987
ISSN: 0021-9738
DOI: 10.1172/jci112789